Description
This gene encodes one ofthe receptors for serotonin, a neurotransmitter with many roles. Mutations inthis gene are associated with susceptibility to schizophrenia andobsessive-compulsive disorder, and are also associated with response to theantidepressant citalopram in patients with major depressive disorder (MDD).MDD patients who also have a mutation in intron 2 of this gene show asignificantly reduced response to citalopram as this antidepressantdownregulates expression of this gene. Multiple transcript variants encodingdifferent isoforms have been found for this gene